The Advanced Variant Configuration screen does not open in classic SAPGUI transactions (e.g. Sales Order processing) and shows an error page or an empty screen or an error message that some requests were not successful in case the S/4HANA embedded Fiori deployment option is used, which means S/4HANA backend and Fiori frontend server system are the same.
Another issue is that a logon page comes up in SAPGUI for Windows when opening the Advanced Variant Configuration screen in case the S/4HANA embedded Fiori deployment option is used.
The reason for the issue in the Advanced Variant Configuration screen is that an origin URL parameter is added to the OData requests sent to the SAP Gateway system, which is prohibited by SAP Gateway in the Co-Deployment scenario.
The logon page issue happens because in SAPGUI for Windows, the SSO logon cannot be established the same way as when accessing the system via Fiori Launchpad and embedded SAPGUI for HTML; instead, a ticket-based logon using special capabilities of the SAPGUI HTML Viewer control is used.
Refer the Notes: 2916536-2916536 – SSO and OData Issue Fix for Advanced Variant Configuration